Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition

Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition

Katsumadain A, a naturally occurring influenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner–Wadsworth–Emmons/oxa Michael addition.

Bibliographic Details
Main Authors: Yongguang Wang, Ruiyang Bao, Shengdian Huang, Yefeng Tang
Format: Article
Language:English
Published: Beilstein-Institut 2013-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
bioinspired synthesis
catalysis
katsumadain A
natural product
organocatalytic 1,4-conjugate addition
Online Access:https://doi.org/10.3762/bjoc.9.182

Internet

https://doi.org/10.3762/bjoc.9.182

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