Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.

The NLRP3 inflammasome complex is responsible for maturation of the pro-inflammatory cytokine, IL-1β. Mutations in NLRP3 are responsible for the cryopyrinopathies, a spectrum of conditions including neonatal-onset multisystem inflammatory disease (NOMID). While excessive production of IL-1β and syst...

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Bibliographic Details
Main Authors: Sheri L Bonar, Susannah D Brydges, James L Mueller, Matthew D McGeough, Carla Pena, Debbie Chen, Susan K Grimston, Cynthia L Hickman-Brecks, Soumya Ravindran, Audrey McAlinden, Deborah V Novack, Daniel L Kastner, Roberto Civitelli, Hal M Hoffman, Gabriel Mbalaviele
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338787?pdf=render

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http://europepmc.org/articles/PMC3338787?pdf=render

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