Unique molecular signature in mucolipidosis type IV microglia

Unique molecular signature in mucolipidosis type IV microglia

Abstract Background Lysosomal storage diseases (LSD) are a large family of inherited disorders characterized by abnormal endolysosomal accumulation of cellular material due to catabolic enzyme and transporter deficiencies. Depending on the affected metabolic pathway, LSD manifest with somatic or cen...

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Main Authors: Antony Cougnoux, Rebecca A. Drummond, Mason Fellmeth, Fatemeh Navid, Amanda L. Collar, James Iben, Ashok B. Kulkarni, James Pickel, Raphael Schiffmann, Christopher A. Wassif, Niamh X. Cawley, Michail S. Lionakis, Forbes D. Porter
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Mucolipidosis type IV
Fabry disease
Microglia
CCL5
Neuroinflammation
Lysosomal disease
Online Access:https://doi.org/10.1186/s12974-019-1672-4

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