Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells.

Gemcitabine eliminates double minute chromosomes from human ovarian cancer cells.

Double minute chromosomes are cytogenetic manifestations of gene amplification frequently seen in cancer cells. Genes amplified on double minute chromosomes include oncogenes and multi-drug resistant genes. These genes encode proteins which contribute to cancer formation, cancer progression, and dev...

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Bibliographic Details
Main Authors: Lisa Yu, Yan Zhao, Chao Quan, Wei Ji, Jing Zhu, Yun Huang, Rongwei Guan, Donglin Sun, Yan Jin, Xiangning Meng, Chunyu Zhang, Yang Yu, Jing Bai, Wenjing Sun, Songbin Fu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3750019?pdf=render

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