| Summary: | Background: It is important for older adults to prevent sarcopenia, but there are not currently effective methods to maintain or improve skeletal muscle function or immune function in this population. The goal of this study was to observe the effects of a 12-week resistance exercise program with fermented soybean supplementation on glucose tolerance and myokine expression in middle-aged obese rats in regard to body composition and immune senescence. Methods: Subjects were randomly assigned to four groups: control (CON), soybean (SO), resistance exercise (RE), and soybean plus resistance exercise (SR). Resistance exercise involved ladder climbing, and soybean supplementation comprised 24% of total calories from soybean protein. Obesity was induced with 6 weeks of a high-fat diet, and then the group-specific procedures were conducted for the following 12 weeks. Results: There were no significant differences between the groups in regard to daily dietary intake and body weight. The SO group had significantly higher intraperitoneal fat levels compared to the CON group (P＜0.05), and a significantly lower lean body mass (P＜0.05). The glycemic response of the SO group and SR group showed significantly higher improvements compared to the CON group and RE group (P＜0.05). The expression of myokines related to immune senescence was significantly lower in the SO group (P＜0.05). Conclusion: Fermented soy beans helped improve glucose tolerance when it was applied with and without resistance exercise, with a significant reduction in the expression of inflammatory factors related to immune senescence in skeletal muscle.
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