Chromeno[3,4-<i>b</i>]Xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors

Chromeno[3,4-<i>b</i>]Xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors

Alzheimer’s disease (AD) is a complex multifactorial disorder, mainly characterized by the progressive loss of memory and cognitive, motor, and functional capacity. The absence of effective therapies available for AD alongside the consecutive failures in the central nervous system (CNS) drug develop...

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Bibliographic Details
Main Authors: Daniela Malafaia, Ana Oliveira, Pedro A. Fernandes, Maria J. Ramos, Hélio M. T. Albuquerque, Artur M. S. Silva
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
AChE
Aβ-aggregation
dual-target inhibitors
chromeno[3,4-<i>b</i>]xanthones
Online Access:https://www.mdpi.com/1422-0067/22/8/4145

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