Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein.

Enhanced platelet activation mediates the accelerated angiogenic switch in mice lacking histidine-rich glycoprotein.

BACKGROUND: The heparin-binding plasma protein histidine-rich glycoprotein (HRG; alternatively, HRGP/HPRG) can suppress tumor angiogenesis and growth in vitro and in vivo. Mice lacking the HRG gene are viable and fertile, but have an enhanced coagulation resulting in decreased bleeding times. In add...

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Bibliographic Details
Main Authors: Maria Ringvall, Åsa Thulin, Lei Zhang, Jessica Cedervall, Nobuko Tsuchida-Straeten, Willi Jahnen-Dechent, Agneta Siegbahn, Anna-Karin Olsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3022027?pdf=render

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http://europepmc.org/articles/PMC3022027?pdf=render

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