Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity

Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity

The global burden of enteric dysfunction and diarrhoeal disease remains a formidable problem that requires novel interventions. This study investigated the immune-modulatory capacity of bran across rice varieties with phytochemical differences. 129SvEvTac mice were fed a 10% rice bran or control die...

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Main Authors: Andrew Goodyear, Ajay Kumar, E.J. Ehrhart, Kelly S. Swanson, Michael A. Grusak, Jan E. Leach, Steven W. Dow, Anna McClung, Elizabeth P. Ryan
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Functional Foods
Subjects:
Rice bran
Salmonella
Fatty acid
Innate immunity
Regulatory T cells
Minerals
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615004120
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spelling doaj-7508c019da1748bfa61a5d707686753d2021-04-29T04:45:12ZengElsevierJournal of Functional Foods1756-46462015-10-0118653664Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunityAndrew Goodyear0Ajay Kumar1E.J. Ehrhart2Kelly S. Swanson3Michael A. Grusak4Jan E. Leach5Steven W. Dow6Anna McClung7Elizabeth P. Ryan8Department of Environmental and Radiological Health, Colorado State University, Fort Collins, CO 80523, USA; Second Genome, South San Francisco, CA 94080, USADepartment of Environmental and Radiological Health, Colorado State University, Fort Collins, CO 80523, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USADepartment of Animal Sciences, University of Illinois, Urbana, IL 61801, USADepartment of Pediatrics, USDA-ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USADepartment of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, CO 80523, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USAUSDA-ARS Dale Bumpers National Rice Research Center, Stuttgart, AR 72160, USADepartment of Environmental and Radiological Health, Colorado State University, Fort Collins, CO 80523, USA; Corresponding author. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80526-1680, USA. Tel.: +1 970 491 1536; fax: +1 970 491 7569.The global burden of enteric dysfunction and diarrhoeal disease remains a formidable problem that requires novel interventions. This study investigated the immune-modulatory capacity of bran across rice varieties with phytochemical differences. 129SvEvTac mice were fed a 10% rice bran or control diet followed by infection with Salmonella enterica. Faecal shedding titres were quantified and flow cytometry was used to investigate intestinal immunity. The largest protection against Salmonella colonization was observed with IAC600 variety. Reduced faecal shedding correlated with increased levels of boron, soluble fibre, vitamin E isomers, and fatty acids. IAC600 and Red Wells rice bran modulated small intestinal neutrophils, macrophages, interdigitating dendritic cells, CD8+, γδ, and regulatory T cells, as well as CD8+ and γδ T cells in the mesenteric lymph nodes. Rice bran is a promising functional food and merits evaluation for the prevention of Salmonella colonization and regulation of intestinal immunity in people.http://www.sciencedirect.com/science/article/pii/S1756464615004120Rice branSalmonellaFatty acidInnate immunityRegulatory T cellsMinerals
collection DOAJ
language English
format Article
sources DOAJ
author Andrew Goodyear
Ajay Kumar
E.J. Ehrhart
Kelly S. Swanson
Michael A. Grusak
Jan E. Leach
Steven W. Dow
Anna McClung
Elizabeth P. Ryan
spellingShingle Andrew Goodyear
Ajay Kumar
E.J. Ehrhart
Kelly S. Swanson
Michael A. Grusak
Jan E. Leach
Steven W. Dow
Anna McClung
Elizabeth P. Ryan
Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
Journal of Functional Foods
Rice bran
Salmonella
Fatty acid
Innate immunity
Regulatory T cells
Minerals
author_facet Andrew Goodyear
Ajay Kumar
E.J. Ehrhart
Kelly S. Swanson
Michael A. Grusak
Jan E. Leach
Steven W. Dow
Anna McClung
Elizabeth P. Ryan
author_sort Andrew Goodyear
title Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
title_short Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
title_full Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
title_fullStr Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
title_full_unstemmed Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity
title_sort dietary rice bran supplementation prevents salmonella colonization differentially across varieties and by priming intestinal immunity
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2015-10-01
description The global burden of enteric dysfunction and diarrhoeal disease remains a formidable problem that requires novel interventions. This study investigated the immune-modulatory capacity of bran across rice varieties with phytochemical differences. 129SvEvTac mice were fed a 10% rice bran or control diet followed by infection with Salmonella enterica. Faecal shedding titres were quantified and flow cytometry was used to investigate intestinal immunity. The largest protection against Salmonella colonization was observed with IAC600 variety. Reduced faecal shedding correlated with increased levels of boron, soluble fibre, vitamin E isomers, and fatty acids. IAC600 and Red Wells rice bran modulated small intestinal neutrophils, macrophages, interdigitating dendritic cells, CD8+, γδ, and regulatory T cells, as well as CD8+ and γδ T cells in the mesenteric lymph nodes. Rice bran is a promising functional food and merits evaluation for the prevention of Salmonella colonization and regulation of intestinal immunity in people.
topic Rice bran
Salmonella
Fatty acid
Innate immunity
Regulatory T cells
Minerals
url http://www.sciencedirect.com/science/article/pii/S1756464615004120
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AT michaelagrusak dietaryricebransupplementationpreventssalmonellacolonizationdifferentiallyacrossvarietiesandbyprimingintestinalimmunity
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