NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.
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Nature Publishing Group
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17101-y |
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doaj-74f1f51789f34696aeebabd489877a8c2021-07-04T11:47:49ZengNature Publishing GroupNature Communications2041-17232020-07-0111111910.1038/s41467-020-17101-yNSs amyloid formation is associated with the virulence of Rift Valley fever virus in micePsylvia Léger0Eliana Nachman1Karsten Richter2Carole Tamietti3Jana Koch4Robin Burk5Susann Kummer6Qilin Xin7Megan Stanifer8Michèle Bouloy9Steeve Boulant10Hans-Georg Kräusslich11Xavier Montagutelli12Marie Flamand13Carmen Nussbaum-Krammer14Pierre-Yves Lozach15CellNetworks—Cluster of Excellence and Virology, University Hospital HeidelbergCenter for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH AllianceDKFZStructural Virology, Institut PasteurCellNetworks—Cluster of Excellence and Virology, University Hospital HeidelbergCenter for Integrative Infectious Diseases Research (CIID), Virology, University Hospital HeidelbergCenter for Integrative Infectious Diseases Research (CIID), Virology, University Hospital HeidelbergUniversity Lyon, INRAE, EPHE, IVPCCenter for Integrative Infectious Diseases Research (CIID), Virology, University Hospital HeidelbergUnité de Génétique Moléculaire des Bunyavirus, Institut PasteurCenter for Integrative Infectious Diseases Research (CIID), Virology, University Hospital HeidelbergCenter for Integrative Infectious Diseases Research (CIID), Virology, University Hospital HeidelbergMouse Genetics Laboratory, Institut PasteurStructural Virology, Institut PasteurCenter for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH AllianceCellNetworks—Cluster of Excellence and Virology, University Hospital HeidelbergRift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice.https://doi.org/10.1038/s41467-020-17101-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach |
| spellingShingle |
Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice Nature Communications |
| author_facet |
Psylvia Léger Eliana Nachman Karsten Richter Carole Tamietti Jana Koch Robin Burk Susann Kummer Qilin Xin Megan Stanifer Michèle Bouloy Steeve Boulant Hans-Georg Kräusslich Xavier Montagutelli Marie Flamand Carmen Nussbaum-Krammer Pierre-Yves Lozach |
| author_sort |
Psylvia Léger |
| title |
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice |
| title_short |
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice |
| title_full |
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice |
| title_fullStr |
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice |
| title_full_unstemmed |
NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice |
| title_sort |
nss amyloid formation is associated with the virulence of rift valley fever virus in mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-07-01 |
| description |
Rift Valley fever virus (RVFV) can cause severe diseases in humans, including encephalitis. Here the authors show that NSs, the major virulence factor of RVFV, is an amyloidogenic protein forming fibrils in infected mouse brains and causing increased mortality in mice. |
| url |
https://doi.org/10.1038/s41467-020-17101-y |
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