Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress

Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress

The prefrontal cortex (PFC) provides top-down regulation of behavior, cognition, and emotion, including spatial working memory. However, these PFC abilities are greatly impaired by exposure to acute or chronic stress. Chronic stress exposure in rats induces atrophy of PFC dendrites and spines that c...

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Bibliographic Details
Main Authors:	Avis Brennan Hains, Yoko Yabe, Amy F.T. Arnsten
Format:	Article
Language:	English
Published:	Elsevier 2015-01-01
Series:	Neurobiology of Stress
Subjects:	Working memory Post-traumatic stress disorder Norepinephrine Attention deficit hyperactivity disorder
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352289515000223

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