High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates

Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Pa...

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Main Authors: Salman Sohrabi, Danielle E. Mor, Rachel Kaletsky, William Keyes, Coleen T. Murphy
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01731-z
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spelling doaj-74da37c3af4d4181ad273528c69473162021-02-21T12:27:23ZengNature Publishing GroupCommunications Biology2399-36422021-02-01411910.1038/s42003-021-01731-zHigh-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidatesSalman Sohrabi0Danielle E. Mor1Rachel Kaletsky2William Keyes3Coleen T. Murphy4Department of Molecular Biology & Lewis Sigler Institute for Integrative Genomics, Princeton UniversityDepartment of Molecular Biology & Lewis Sigler Institute for Integrative Genomics, Princeton UniversityDepartment of Molecular Biology & Lewis Sigler Institute for Integrative Genomics, Princeton UniversityDepartment of Molecular Biology & Lewis Sigler Institute for Integrative Genomics, Princeton UniversityDepartment of Molecular Biology & Lewis Sigler Institute for Integrative Genomics, Princeton UniversitySalman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Parkinson’s disease.https://doi.org/10.1038/s42003-021-01731-z
collection DOAJ
language English
format Article
sources DOAJ
author Salman Sohrabi
Danielle E. Mor
Rachel Kaletsky
William Keyes
Coleen T. Murphy
spellingShingle Salman Sohrabi
Danielle E. Mor
Rachel Kaletsky
William Keyes
Coleen T. Murphy
High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
Communications Biology
author_facet Salman Sohrabi
Danielle E. Mor
Rachel Kaletsky
William Keyes
Coleen T. Murphy
author_sort Salman Sohrabi
title High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_short High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_full High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_fullStr High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_full_unstemmed High-throughput behavioral screen in C. elegans reveals Parkinson’s disease drug candidates
title_sort high-throughput behavioral screen in c. elegans reveals parkinson’s disease drug candidates
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-02-01
description Salman Sohrabi et al. develop an automated, high-throughput assay to study spasm-like curling behavior in C. elegans, which is related to motor control symptoms in Parkinson’s disease. They apply this screening approach to identify four candidate drugs for potential late-in-life interventions for Parkinson’s disease.
url https://doi.org/10.1038/s42003-021-01731-z
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AT williamkeyes highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates
AT coleentmurphy highthroughputbehavioralscreenincelegansrevealsparkinsonsdiseasedrugcandidates
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