PTEN deletion increases hippocampal granule cell excitability in male and female mice

PTEN deletion increases hippocampal granule cell excitability in male and female mice

Deletion of the mTOR pathway inhibitor PTEN from postnatally-generated hippocampal dentate granule cells causes epilepsy. Here, we conducted field potential, whole cell recording and single cell morphology studies to begin to elucidate the mechanisms by which granule cell-specific PTEN-loss produces...

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Bibliographic Details
Main Authors: Victor R. Santos, Raymund Y.K. Pun, Salwa R. Arafa, Candi L. LaSarge, Shane Rowley, Shadi Khademi, Tom Bouley, Katherine D. Holland, Norberto Garcia-Cairasco, Steve C. Danzer
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Epileptogenesis
mTOR
Dentate gyrus
Hippocampus
Mouse models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302048

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