Biofilm formation by blood isolates of Candida parapsilosis sensu stricto in the presence of a hyperglycidic solution at comparable concentrations of total parenteral nutrition

Biofilm formation by blood isolates of Candida parapsilosis sensu stricto in the presence of a hyperglycidic solution at comparable concentrations of total parenteral nutrition

Abstract INTRODUCTION: Administration of total parenteral nutrition (TPN) via catheters increases the risk for candidemia from Candida parapsilosis. METHODS: C. parapsilosis sensu stricto blood isolates were evaluated for ability total biomass biofilm formation and morphogenesis in presence of glu...

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Bibliographic Details
Main Authors: Thalita Caroline Herek, Vinícius Ribeiro Menegazzo, Mayara Baptistucci Ogaki, Hugo Felix Perini, Luciana Furlaneto Maia, Marcia Cristina Furlaneto
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2019-01-01
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Candida parapsilosis
Biofilm
Glucose
TPN
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100607&lng=en&tlng=en
Description
Summary:Abstract INTRODUCTION: Administration of total parenteral nutrition (TPN) via catheters increases the risk for candidemia from Candida parapsilosis. METHODS: C. parapsilosis sensu stricto blood isolates were evaluated for ability total biomass biofilm formation and morphogenesis in presence of glucose at TPN equivalent concentrations. RESULTS: Biofilms were increased at high glucose concentrations (25-30%) compared to the control medium. Significant increase in filamentous forms was observed in cultures with 30% glucose. CONCLUSIONS: Biofilm formation by C. parapsilosis sensu stricto in hyperglycidic medium may contribute to its pathogenic potential for fungemia related to TPN catheters.
ISSN:1678-9849

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