Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice

Abstract Background Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL). Methods In this and o...

Full description

Bibliographic Details
Main Authors: Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock, Linda J. Bendall
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Biomarker Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40364-018-0120-4