Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway

Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway

Cortistatin-14 (CST-14), a recently discovered cyclic neuropeptide, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus. However, the role of CST-14 in the control of depression p...

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Bibliographic Details
Main Authors: JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
cortistatin-14
antidepressant effects
somatostatin receptors (SSTRs)
ghrelin receptor
GABAA receptor
intranasal
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00767/full

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