Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice

Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice

Pungent spice constituents such as piperine, capsaicin and [6]-gingerol consumed via daily diet or traditional Chinese medicine, have been reported to possess various pharmacological activities. These dietary phytochemicals have also been reported to inhibit P-glycoprotein (P-gp) in vitro and act as...

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Bibliographic Details
Main Authors: Tae Hwan Kim, Soyoung Shin, Sun Dong Yoo, Beom Soo Shin
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
P-glycoprotein
doxorubicin
pharmacokinetics
piperine
capsaicin
[6]-gingerol
Online Access:http://www.mdpi.com/1420-3049/23/2/349

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