Clinicopathological characterization of SMAD4-mutated intestinal adenocarcinomas: A case-control study.

Clinicopathological characterization of SMAD4-mutated intestinal adenocarcinomas: A case-control study.

The SMAD4 tumor suppressor gene product inhibits transforming growth factor-β-mediated signaling and is mutated in ~10% of colorectal carcinomas. The prognostic significance of SMAD4 mutations has been controversial. We studied the pathological and clinical characteristics of SMAD4-mutated intestina...

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Bibliographic Details
Main Authors:	Xiaoyan Liao, Yansheng Hao, Xiaofei Zhang, Stephen Ward, Jane Houldsworth, Alexandros D Polydorides, Noam Harpaz
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0212142

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