Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma

Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and is frequently accompanied by the genetic features of von Hippel–Lindau (VHL) loss. VHL loss increases the expression of hypoxia-inducible factors (HIFs) and their targets, including epiderm...

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Bibliographic Details
Main Authors: Yongchang Lai, Zhijian Zhao, Tao Zeng, Xiongfa Liang, Dong Chen, Xiaolu Duan, Guohua Zeng, Wenqi Wu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cancer Cell International
Subjects:
TKIs
Crosstalk
mRCC
VEGFR
HIFs
RTKs
Online Access:http://link.springer.com/article/10.1186/s12935-018-0530-2

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