Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function

SARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary...

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Main Authors: Iatsenko Viktoria, Boyarshin Konstantin, Bespalova Olga, Klyueva Violetta, Kurkina Yuliya, Batlutskaya Irina
Format: Article
Language:English
Published: EDP Sciences 2021-01-01
Series:BIO Web of Conferences
Online Access:https://www.bio-conferences.org/articles/bioconf/full_html/2021/02/bioconf_ils2021_05008/bioconf_ils2021_05008.html
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spelling doaj-74b551d7710b45c588163cec8a4ad5372021-05-04T12:12:32ZengEDP SciencesBIO Web of Conferences2117-44582021-01-01300500810.1051/bioconf/20213005008bioconf_ils2021_05008Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical functionIatsenko ViktoriaBoyarshin KonstantinBespalova OlgaKlyueva ViolettaKurkina YuliyaBatlutskaya IrinaSARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary structures demonstrate very low homology and different calculating parameters. This time they both are affected by stabilizing selection and in natural viral populations do not tend to be deleted. The question whether in this case very different proteins could share the same function rises from the present data.https://www.bio-conferences.org/articles/bioconf/full_html/2021/02/bioconf_ils2021_05008/bioconf_ils2021_05008.html
collection DOAJ
language English
format Article
sources DOAJ
author Iatsenko Viktoria
Boyarshin Konstantin
Bespalova Olga
Klyueva Violetta
Kurkina Yuliya
Batlutskaya Irina
spellingShingle Iatsenko Viktoria
Boyarshin Konstantin
Bespalova Olga
Klyueva Violetta
Kurkina Yuliya
Batlutskaya Irina
Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
BIO Web of Conferences
author_facet Iatsenko Viktoria
Boyarshin Konstantin
Bespalova Olga
Klyueva Violetta
Kurkina Yuliya
Batlutskaya Irina
author_sort Iatsenko Viktoria
title Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
title_short Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
title_full Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
title_fullStr Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
title_full_unstemmed Low homology between 2019-nCoV Orf8 protein and its SARS-CoV counterparts questions their identical function
title_sort low homology between 2019-ncov orf8 protein and its sars-cov counterparts questions their identical function
publisher EDP Sciences
series BIO Web of Conferences
issn 2117-4458
publishDate 2021-01-01
description SARS-CoV accessory protein Orf8b is involved in suppressing interferon-mediated immune response of the infected cell and this might lead to supposition that the corresponding protein 2019-nCoV Orf8 shares the same role. But the tertiary structures of these proteins are still unknown, and the primary structures demonstrate very low homology and different calculating parameters. This time they both are affected by stabilizing selection and in natural viral populations do not tend to be deleted. The question whether in this case very different proteins could share the same function rises from the present data.
url https://www.bio-conferences.org/articles/bioconf/full_html/2021/02/bioconf_ils2021_05008/bioconf_ils2021_05008.html
work_keys_str_mv AT iatsenkoviktoria lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
AT boyarshinkonstantin lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
AT bespalovaolga lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
AT klyuevavioletta lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
AT kurkinayuliya lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
AT batlutskayairina lowhomologybetween2019ncovorf8proteinanditssarscovcounterpartsquestionstheiridenticalfunction
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