The regulation of protein translation and its implications for cancer

The regulation of protein translation and its implications for cancer

Abstract In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for ant...

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Main Authors: Ping Song, Fan Yang, Hongchuan Jin, Xian Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00444-9
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spelling doaj-74b2169cd0b74d8ebf7382a0536d808f2021-02-21T12:19:25ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-02-01611910.1038/s41392-020-00444-9The regulation of protein translation and its implications for cancerPing Song0Fan Yang1Hongchuan Jin2Xian Wang3Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of MedicineKey Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineAbstract In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for anticancer treatments. Protein translation is affected by many factors including translation initiation factors and RNA-binding proteins. Recently, modifications of mRNAs mainly N6-methyladenine (m6A) modification and noncoding RNAs, such as microRNAs and long noncoding RNAs are involved. In this review, we generally summarized the recent advances on the regulation of protein translation by the interplay between mRNA modifications and ncRNAs. By doing so, we hope this review could offer some hints for the development of novel approaches in precision therapy of human cancers.https://doi.org/10.1038/s41392-020-00444-9
collection DOAJ
language English
format Article
sources DOAJ
author Ping Song
Fan Yang
Hongchuan Jin
Xian Wang
spellingShingle Ping Song
Fan Yang
Hongchuan Jin
Xian Wang
The regulation of protein translation and its implications for cancer
Signal Transduction and Targeted Therapy
author_facet Ping Song
Fan Yang
Hongchuan Jin
Xian Wang
author_sort Ping Song
title The regulation of protein translation and its implications for cancer
title_short The regulation of protein translation and its implications for cancer
title_full The regulation of protein translation and its implications for cancer
title_fullStr The regulation of protein translation and its implications for cancer
title_full_unstemmed The regulation of protein translation and its implications for cancer
title_sort regulation of protein translation and its implications for cancer
publisher Nature Publishing Group
series Signal Transduction and Targeted Therapy
issn 2059-3635
publishDate 2021-02-01
description Abstract In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for anticancer treatments. Protein translation is affected by many factors including translation initiation factors and RNA-binding proteins. Recently, modifications of mRNAs mainly N6-methyladenine (m6A) modification and noncoding RNAs, such as microRNAs and long noncoding RNAs are involved. In this review, we generally summarized the recent advances on the regulation of protein translation by the interplay between mRNA modifications and ncRNAs. By doing so, we hope this review could offer some hints for the development of novel approaches in precision therapy of human cancers.
url https://doi.org/10.1038/s41392-020-00444-9
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