Impaired executive functions in experimental model of temporal lobe epilepsy

• Main Authors: Fabiane Ochai Ramos, Luiz Renato Rodrigues Carreiro, Fulvio Alexandre Scorza, Roberta Monterazzo Cysneiros
• Format: Article
• Language: English
• Published: Academia Brasileira de Neurologia (ABNEURO) 2016-06-01
• Series: Arquivos de Neuro-Psiquiatria
• Subjects: epilepsia do lobo temporal; função executiva; pilocarpina; memória de curto prazo
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600470&lng=en&tlng=en
• ISSN: 1678-4227

ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.