Chemotherapy-induced anemia: etiology, pathophysiology, and implications for contemporary practice

• Main Authors: Bryer E, Henry D
• Format: Article
• Language: English
• Published: Dove Medical Press 2018-11-01
• Series: International Journal of Clinical Transfusion Medicine
• Subjects: Chemotherapy-induced anemia; red blood cell transfusion; erythrocyte stimulating agent; iron
• Online Access: https://www.dovepress.com/chemotherapy-induced-anemia-etiology-pathophysiology-and-implications--peer-reviewed-article-IJCTM

Emily Bryer, David Henry Internal Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA Abstract: Chemotherapy-induced anemia (CIA) is a multifaceted entity influenced by a variety of patient- and treatment-specific factors. Some sources of variation within CIA include chemotherapeutic agent as well as dose and administration schedule, type and stage of malignancy, baseline pretreatment hemoglobin, target hemoglobin, timing of intervention (red blood cell transfusion, iron, erythropoietin stimulating agent), nutritional status, renal function, age, and gender. The diversity of patient presentation and symptomatology within the broader spectrum of CIA contributes to the challenge of establishing universal criteria to govern optimal management therapies. This manuscript will review the development and evolution of CIA with an emphasis on assorted therapeutic interventions. Keywords: chemotherapy-induced anemia, red blood cell transfusion, erythrocyte stimulating agent, iron