The effect of intraocular lens material and postoperative therapy on the posterior capsule opacification development after the senile cataract surgery

• Main Authors: Todorović Dušan, Šarenac-Vulović Tatjana, Petrović Nenad, Jovanović Svetlana, Janićijević-Petrović Mirjana, Đoković Danijela, Janićijević Katarina, Srećković Sunčica
• Format: Article
• Language: English
• Published: Serbian Medical Society 2020-01-01
• Series: Srpski Arhiv za Celokupno Lekarstvo
• Subjects: posterior capsule opacification; intraocular lens; nonsteroidal anti-inflammatory drugs; corticosteroids
• Online Access: http://www.doiserbia.nb.rs/img/doi/0370-8179/2020/0370-81791900118T.pdf

Introduction/Objective. The most frequent postoperative complication of a successfully performed phacoemulsification cataract surgery is the development of posterior capsule opacification (PCO). It is caused by the proliferation and migration of the remaining residual epithelial cells. The objective of this study was to investigate the influence of two different intraocular lenses and two different anti-inflammatory drugs on the development of PCO in one-year follow-up period. Methods. Investigation included 120 patients (120 eyes), equally divided into four groups. The first two groups included patients who used non-steroid anti-inflammatory drug (NSAID) postoperatively, while the other groups had corticosteroid therapy. The first and third group got hydrophilic intraocular lenses (IOL), the second and fourth group had hydrophobic IOL. Software program EPCO 2000 was used for the analysis of PCO. Student’s t-test, Wilcoxon test, and ANOVA were used for data analysis and p < 0.05 value was accepted as statistically significant. Results. After the first three postoperative months, patients from NSAID groups had mean PCO score 0.25 Ѓ} 0.03, which was statistically significant higher (p = 0.042) comparing to corticosteroid groups. At the end of the investigation, the best result in PCO preventing was seen in the group of patients with hydrophobic IOL and corticosteroid therapy, with the mean PCO score of 0.47 Ѓ} 0.08. Conclusion. This study has revealed that IOL made of acrylic hydrophobic material seemed to be the right choice when choosing intraocular lens to prevent PCO development. On the other hand, NSAID and corticosteroid therapy have showed similar results in preventing postoperative intraocular inflammation. This fact can be very useful in situations when corticosteroids must be used with great caution.