Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis
Chemical tools to monitor drug-target engagement of endogenous enzymes are essential for preclinical target validation. Here, the authors present a chemical genetics strategy to study target engagement of endogenous kinases, achieving specific labeling and inactivation of FES kinase to provide insig...
Full description
Bibliographic Details
| Main Authors: |
Tom van der Wel,
Riet Hilhorst,
Hans den Dulk,
Tim van den Hooven,
Nienke M. Prins,
Joost A. P. M. Wijnakker,
Bogdan I. Florea,
Eelke B. Lenselink,
Gerard J. P. van Westen,
Rob Ruijtenbeek,
Herman S. Overkleeft,
Allard Kaptein,
Tjeerd Barf,
Mario van der Stelt |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2020-06-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-17027-5
|
|---|
