Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery—a randomized trial

Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery—a randomized trial

Abstract Background Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a systemic inflammatory response is considered a possible etiology. The effects of the glucocorticoid, methylprednisolone, on cereb...

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Bibliographic Details
Main Authors: Mattias Danielson, Björn Reinsfelt, Anne Westerlind, Henrik Zetterberg, Kaj Blennow, Sven-Erik Ricksten
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Aortic valve replacement
Cardiopulmonary bypass
Cerebrospinal fluid
Neuroinflammatory response
Methylprednisolone
Online Access:http://link.springer.com/article/10.1186/s12974-018-1318-y

Internet

http://link.springer.com/article/10.1186/s12974-018-1318-y

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