The Molecular Biology of Brain Metastasis

The Molecular Biology of Brain Metastasis

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Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in mo...

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Main Authors: Gazanfar Rahmathulla, Steven A. Toms, Robert J. Weil
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2012/723541
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spelling doaj-7489591525ec44d489e0b3397f52f27c2020-11-25T00:33:28ZengHindawi LimitedJournal of Oncology1687-84501687-84692012-01-01201210.1155/2012/723541723541The Molecular Biology of Brain MetastasisGazanfar Rahmathulla0Steven A. Toms1Robert J. Weil2The Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Desk S-7, 9500 Euclid Avenue, Cleveland, OH 44195, USADivision of Neurosciences, Department of Neurosurgery, Geisinger Medical Center, Danville, PA 17822, USAThe Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Desk S-7, 9500 Euclid Avenue, Cleveland, OH 44195, USAMetastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM).http://dx.doi.org/10.1155/2012/723541
collection DOAJ
language English
format Article
sources DOAJ
author Gazanfar Rahmathulla
Steven A. Toms
Robert J. Weil
spellingShingle Gazanfar Rahmathulla
Steven A. Toms
Robert J. Weil
The Molecular Biology of Brain Metastasis
Journal of Oncology
author_facet Gazanfar Rahmathulla
Steven A. Toms
Robert J. Weil
author_sort Gazanfar Rahmathulla
title The Molecular Biology of Brain Metastasis
title_short The Molecular Biology of Brain Metastasis
title_full The Molecular Biology of Brain Metastasis
title_fullStr The Molecular Biology of Brain Metastasis
title_full_unstemmed The Molecular Biology of Brain Metastasis
title_sort molecular biology of brain metastasis
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2012-01-01
description Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM).
url http://dx.doi.org/10.1155/2012/723541
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AT stevenatoms molecularbiologyofbrainmetastasis
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