Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites

Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites

It is well known that various physiological factors such as pH, endogenous substances or post-translational modifications can affect the conformational state of human serum albumin (HSA). In a previous study, we reported that both pH- and long chain fatty acid-induced conformational changes can alte...

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Bibliographic Details
Main Authors: Keishi Yamasaki, Koji Nishi, Makoto Anraku, Kazuaki Taguchi, Toru Maruyama, Masaki Otagiri
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Human serum albumin
Metal-catalyzed oxidation
Binding site
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580818300268

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