Coexisting Germline <i>CHEK2</i> and Somatic <i>BRAF</i><sup>V600E</sup> Mutations in Papillary Thyroid Cancer and Their Association with Clinicopathological Features and Disease Course

Coexisting Germline <i>CHEK2</i> and Somatic <i>BRAF</i><sup>V600E</sup> Mutations in Papillary Thyroid Cancer and Their Association with Clinicopathological Features and Disease Course

<i>BRAF</i><sup>V600E</sup> is the most common somatic mutation in papillary thyroid carcinoma (PTC) and the majority of evidence indicates that it is associated with an aggressive clinical course. Germline mutations of the <i>CHEK2</i> gene impair the DNA damage...

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Bibliographic Details
Main Authors: Danuta Gąsior-Perczak, Artur Kowalik, Agnieszka Walczyk, Monika Siołek, Krzysztof Gruszczyński, Iwona Pałyga, Estera Mikina, Tomasz Trybek, Janusz Kopczyński, Ryszard Mężyk, Stanisław Góźdź, Aldona Kowalska
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
papillary thyroid cancer
<i>braf</i> mutation
<i>chek2</i> mutation
risk stratification
response to therapy
Online Access:https://www.mdpi.com/2072-6694/11/11/1744

Internet

https://www.mdpi.com/2072-6694/11/11/1744

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