Remarkable diversity in the enzymes catalyzing the last step in synthesis of the pimelate moiety of biotin.

Biotin synthesis in Escherichia coli requires the functions of the bioH and bioC genes to synthesize the precursor pimelate moiety by use of a modified fatty acid biosynthesis pathway. However, it was previously noted that bioH has been replaced with bioG or bioK within the biotin synthetic gene clu...

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Bibliographic Details
Main Authors: Madelyn M Shapiro, Vandana Chakravartty, John E Cronan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3494674?pdf=render

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