THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE

THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE

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<p>The data of medical records of 101 patients with urothelial bladder cancer (BC) were compared with the results of laboratory detection of human papillomaviruses (HPV) in the tumor tissue samples taken from these patients during transurethral resection. DNA of HPV 16, the major type of the v...

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Main Authors: D. A. Golovina, V. D. Ermilova, A. V. Khachaturyan, N. L. Cheban, V. B. Matveev, G. M. Volgareva
Format: Article
Language:Russian
Published: ABV-press 2014-07-01
Series:Onkourologiâ
Subjects:
bladder cancer
human papillomaviruses
anaplasia
Online Access:http://oncourology.abvpress.ru/index.php/oncur/article/view/11
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spelling doaj-7460ceacea7947519e8e04c1ac5a515d2020-11-25T00:29:50ZrusABV-pressOnkourologiâ 1726-97761996-18122014-07-01101353826THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASED. A. Golovina0V. D. Ermilova1A. V. Khachaturyan2N. L. Cheban3V. B. Matveev4G. M. Volgareva5N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow<p>The data of medical records of 101 patients with urothelial bladder cancer (BC) were compared with the results of laboratory detection of human papillomaviruses (HPV) in the tumor tissue samples taken from these patients during transurethral resection. DNA of HPV 16, the major type of the virus responsible for the occurrence of cervical cancer, was previously detected in 38 samples; and oncogenes E6 and E7 mRNA and HPV 16 E7 oncoprotein were found in 13 of these samples. Comparison of HPV-positive and HPV-negative groups revealed that HPV-positive BC showed higher cell anaplasia than HPV-negative one; moreover, primary cancer was HPV-positive more frequently than recurrent cancer. Sex, age, muscular layer invasion did not correlate with the HPV positivity of BC.</p><p> </p>http://oncourology.abvpress.ru/index.php/oncur/article/view/11bladder cancerhuman papillomavirusesanaplasia
collection DOAJ
language Russian
format Article
sources DOAJ
author D. A. Golovina
V. D. Ermilova
A. V. Khachaturyan
N. L. Cheban
V. B. Matveev
G. M. Volgareva
spellingShingle D. A. Golovina
V. D. Ermilova
A. V. Khachaturyan
N. L. Cheban
V. B. Matveev
G. M. Volgareva
THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
Onkourologiâ
bladder cancer
human papillomaviruses
anaplasia
author_facet D. A. Golovina
V. D. Ermilova
A. V. Khachaturyan
N. L. Cheban
V. B. Matveev
G. M. Volgareva
author_sort D. A. Golovina
title THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
title_short THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
title_full THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
title_fullStr THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
title_full_unstemmed THE HPV STATUS IN BLADDER CANCER, TUMOR MORPHOLOGICAL CHARACTERISTICS, AND CLINICAL FEATURES OF THE DISEASE
title_sort hpv status in bladder cancer, tumor morphological characteristics, and clinical features of the disease
publisher ABV-press
series Onkourologiâ
issn 1726-9776
1996-1812
publishDate 2014-07-01
description <p>The data of medical records of 101 patients with urothelial bladder cancer (BC) were compared with the results of laboratory detection of human papillomaviruses (HPV) in the tumor tissue samples taken from these patients during transurethral resection. DNA of HPV 16, the major type of the virus responsible for the occurrence of cervical cancer, was previously detected in 38 samples; and oncogenes E6 and E7 mRNA and HPV 16 E7 oncoprotein were found in 13 of these samples. Comparison of HPV-positive and HPV-negative groups revealed that HPV-positive BC showed higher cell anaplasia than HPV-negative one; moreover, primary cancer was HPV-positive more frequently than recurrent cancer. Sex, age, muscular layer invasion did not correlate with the HPV positivity of BC.</p><p> </p>
topic bladder cancer
human papillomaviruses
anaplasia
url http://oncourology.abvpress.ru/index.php/oncur/article/view/11
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