Astrocytic Interleukin-15 Reduces Pathology of Neuromyelitis Optica in Mice

Astrocytic Interleukin-15 Reduces Pathology of Neuromyelitis Optica in Mice

Astrocyte loss induced by neuromyelitis optica (NMO)-IgG and complement-dependent cytotoxicity (CDC) is the hallmark of NMO pathology. The survival of astrocytes is thought to reflect astrocyte exposure to environmental factors in the CNS and the response of astrocytes to these factors. However, sti...

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Bibliographic Details
Main Authors: Zhiguo Li, Jinrui Han, Honglei Ren, Cun-Gen Ma, Fu-Dong Shi, Qiang Liu, Minshu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
astrocytes
complement-dependent cytotoxicity
neuromyelitis optica-IgG
IL-15
neuromyelitis optica
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00523/full

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