Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.

Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancer.

BRIP1 interacts with BRCA1 and functions in regulating DNA double strand break repair pathways. Germline BRIP1 mutations are associated with breast cancer and Fanconi anemia. Thus, common variants in the BRIP1 are candidates for breast and ovarian cancer susceptibility.We used a SNP tagging approach...

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Bibliographic Details
Main Authors: Honglin Song, Susan J Ramus, Susanne Krüger Kjaer, Estrid Hogdall, Richard A Dicioccio, Alice S Whittemore, Valerie McGuire, Claus Hogdall, Ian J Jacobs, Douglas F Easton, Bruce A J Ponder, Alison M Dunning, Simon A Gayther, Paul D P Pharoah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1800910?pdf=render

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