Isoniazid in autoimmunity: a trigger for multiple sclerosis?

Isoniazid in autoimmunity: a trigger for multiple sclerosis?

Isoniazid (INH) is a prodrug activated by the mycobacterial enzyme KatG, a multifunctional catalase peroxidase. KatG converts INH to reactive antimycobacterial species. For decades, an association between INH and drug-induced lupus erythematosus has been recognized. We present the case of a patient...

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Bibliographic Details
Main Authors: Bardia Nourbakhsh, Olaf Stüve
Format: Article
Language:English
Published: SAGE Publishing 2014-09-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/1756285614540361
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spelling doaj-745a520661eb432e9fedd932c7548b712020-11-25T03:48:01ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28561756-28642014-09-01710.1177/1756285614540361Isoniazid in autoimmunity: a trigger for multiple sclerosis?Bardia NourbakhshOlaf StüveIsoniazid (INH) is a prodrug activated by the mycobacterial enzyme KatG, a multifunctional catalase peroxidase. KatG converts INH to reactive antimycobacterial species. For decades, an association between INH and drug-induced lupus erythematosus has been recognized. We present the case of a patient with primary progressive multiple sclerosis whose disease commenced weeks after initiating INH therapy for prevention of tuberculosis. Possible mechanisms by which INH may trigger autoimmunity in humans are discussed.https://doi.org/10.1177/1756285614540361
collection DOAJ
language English
format Article
sources DOAJ
author Bardia Nourbakhsh
Olaf Stüve
spellingShingle Bardia Nourbakhsh
Olaf Stüve
Isoniazid in autoimmunity: a trigger for multiple sclerosis?
Therapeutic Advances in Neurological Disorders
author_facet Bardia Nourbakhsh
Olaf Stüve
author_sort Bardia Nourbakhsh
title Isoniazid in autoimmunity: a trigger for multiple sclerosis?
title_short Isoniazid in autoimmunity: a trigger for multiple sclerosis?
title_full Isoniazid in autoimmunity: a trigger for multiple sclerosis?
title_fullStr Isoniazid in autoimmunity: a trigger for multiple sclerosis?
title_full_unstemmed Isoniazid in autoimmunity: a trigger for multiple sclerosis?
title_sort isoniazid in autoimmunity: a trigger for multiple sclerosis?
publisher SAGE Publishing
series Therapeutic Advances in Neurological Disorders
issn 1756-2856
1756-2864
publishDate 2014-09-01
description Isoniazid (INH) is a prodrug activated by the mycobacterial enzyme KatG, a multifunctional catalase peroxidase. KatG converts INH to reactive antimycobacterial species. For decades, an association between INH and drug-induced lupus erythematosus has been recognized. We present the case of a patient with primary progressive multiple sclerosis whose disease commenced weeks after initiating INH therapy for prevention of tuberculosis. Possible mechanisms by which INH may trigger autoimmunity in humans are discussed.
url https://doi.org/10.1177/1756285614540361
work_keys_str_mv AT bardianourbakhsh isoniazidinautoimmunityatriggerformultiplesclerosis
AT olafstuve isoniazidinautoimmunityatriggerformultiplesclerosis
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