Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological conditions, pUMOD accumulates within the tubular lum...

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Bibliographic Details
Main Authors: Roland Immler, Bärbel Lange-Sperandio, Tobias Steffen, Heike Beck, Ina Rohwedder, Jonas Roth, Matteo Napoli, Georg Hupel, Frederik Pfister, Bastian Popper, Bernd Uhl, Hanna Mannell, Christoph A. Reichel, Volker Vielhauer, Jürgen Scherberich, Markus Sperandio, Monika Pruenster
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
uromodulin
damage associated molecular pattern (DAMP)
inflammation
leukocyte recruitment
kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588245/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.588245/full

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