A novel compound isolated from Sclerochloa dura has anti-inflammatory effects
The activation of PLA2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-s...
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Serbian Chemical Society
2016-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500055B.pdf |
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doaj-744f107aa1ad4bceb5b2a120ad4f6eff2020-11-25T01:07:31ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212016-01-0181111210.2298/JSC150119055B0352-51391500055BA novel compound isolated from Sclerochloa dura has anti-inflammatory effectsBukhari Syed Majid0Feuerherm Astrid Jullumstrø1Tunset Hanna Maja2Isaksen Stian Moe3Sæther Mari4Thvedt Thor Håkon Krane5Gonzalez Susana Villa6Schmid Rudolf7Brunsvik Anders8Fuglseth Erik9Zlatković Bojan10Johansen Berit11Simić Nebojša12Norwegian University of Sciences and Technology, Department of Chemistry, Trondheim, Norway + COMSATS Institute of Information Technology, Department of Chemistry, Abbottabad, PakistanNorwegian University of Sciences and Technology, Department of Biology, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Biology, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Chemistry, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Biology, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Chemistry, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Chemistry, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Chemistry, Trondheim, NorwaySINTEF Materials and Chemistry, Department of Mass Spectrometry, Trondheim, NorwayNorwegian University of Sciences and Technology, Technology transfer office, Trondheim, NorwayDepartment of Biology, NišNorwegian University of Sciences and Technology, Department of Biology, Trondheim, NorwayNorwegian University of Sciences and Technology, Department of Chemistry, Trondheim, NorwayThe activation of PLA2 by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, the non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. By using AA release assay as a guide for biological and anti-inflammatory activity, novel compound 1-O-(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl)-glycerol (1) together with five known compounds isovitexin, byzantionoside B, tricin 4’-O-(erythro-β-guaiacylglyceryl) ether 7-O-β-glucopyranoside, 1-O-feruloyl glycerol and tricin 7-glucoside were isolated from the methanol extract of the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20 column chromatography, preparative HPLC and semi-preparative HPLC). All isolated compounds were identified using spectroscopic NMR spectroscopy and MS spectrometry. Novel compound (1) was found to be an effective inhibitor of AA release with an IC50 value of 0.09 ± 0.03 mg mL-1.http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500055B.pdfarachidonic acidanti-inflammatory activityPLA2 inhibitorSephadex LH-20HPLCCell line SW982 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bukhari Syed Majid Feuerherm Astrid Jullumstrø Tunset Hanna Maja Isaksen Stian Moe Sæther Mari Thvedt Thor Håkon Krane Gonzalez Susana Villa Schmid Rudolf Brunsvik Anders Fuglseth Erik Zlatković Bojan Johansen Berit Simić Nebojša |
| spellingShingle |
Bukhari Syed Majid Feuerherm Astrid Jullumstrø Tunset Hanna Maja Isaksen Stian Moe Sæther Mari Thvedt Thor Håkon Krane Gonzalez Susana Villa Schmid Rudolf Brunsvik Anders Fuglseth Erik Zlatković Bojan Johansen Berit Simić Nebojša A novel compound isolated from Sclerochloa dura has anti-inflammatory effects Journal of the Serbian Chemical Society arachidonic acid anti-inflammatory activity PLA2 inhibitor Sephadex LH-20 HPLC Cell line SW982 |
| author_facet |
Bukhari Syed Majid Feuerherm Astrid Jullumstrø Tunset Hanna Maja Isaksen Stian Moe Sæther Mari Thvedt Thor Håkon Krane Gonzalez Susana Villa Schmid Rudolf Brunsvik Anders Fuglseth Erik Zlatković Bojan Johansen Berit Simić Nebojša |
| author_sort |
Bukhari Syed Majid |
| title |
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects |
| title_short |
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects |
| title_full |
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects |
| title_fullStr |
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects |
| title_full_unstemmed |
A novel compound isolated from Sclerochloa dura has anti-inflammatory effects |
| title_sort |
novel compound isolated from sclerochloa dura has anti-inflammatory effects |
| publisher |
Serbian Chemical Society |
| series |
Journal of the Serbian Chemical Society |
| issn |
0352-5139 1820-7421 |
| publishDate |
2016-01-01 |
| description |
The activation of PLA2 by means of pro-inflammatory cytokines results in the
subsequent release of arachidonic acid (AA) and generates eicosanoids, which
further propagate inflammation. By 6the cyclooxygenases (COX1/2) responsible
for the enzymatic conversion of AA to eicosanoids, the non-steroidal
anti-inflammatory drugs are effective in relieving the pain and discomfort of
inflammation. By using AA release assay as a guide for biological and
anti-inflammatory activity, novel compound
1-O-(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl)-glycerol (1) together
with five known compounds isovitexin, byzantionoside B, tricin
4’-O-(erythro-β-guaiacylglyceryl) ether 7-O-β-glucopyranoside, 1-O-feruloyl
glycerol and tricin 7-glucoside were isolated from the methanol extract of
the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20
column chromatography, preparative HPLC and semi-preparative HPLC). All
isolated compounds were identified using spectroscopic NMR spectroscopy and
MS spectrometry. Novel compound (1) was found to be an effective inhibitor of
AA release with an IC50 value of 0.09 ± 0.03 mg mL-1. |
| topic |
arachidonic acid anti-inflammatory activity PLA2 inhibitor Sephadex LH-20 HPLC Cell line SW982 |
| url |
http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500055B.pdf |
| work_keys_str_mv |
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