Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being critically involved in fibrinolysis and wound healing, emerging evidence indicates that PAI-1 plays an important role in many dis...

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Bibliographic Details
Main Authors: Machteld Sillen, Stephen D. Weeks, Sergei V. Strelkov, Paul J. Declerck
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
plasminogen activator inhibitor 1
cardiovascular disease
fibrinolysis
single-domain antibodies
nanobodies
protein–protein interaction
Online Access:https://www.mdpi.com/1422-0067/21/16/5859

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