Comparative characteristics of the transcriptional activity of CDH1, CTNNB1, VEGFA genes and expression of proteins E-cadherin, β-catenin and VEGFA, coded by these genes in metastatic and non-metastatic endometrioid endometrial carcinoma

Comparative characteristics of the transcriptional activity of CDH1, CTNNB1, VEGFA genes and expression of proteins E-cadherin, β-catenin and VEGFA, coded by these genes in metastatic and non-metastatic endometrioid endometrial carcinoma

The violation of Wnt-signaling pathway and cyclic neoangiogenesis is early events in endometrial carcinogenesis. In this process an important role is played by epigenetic modifications and mutations of CDH1, CTNNB1, VEGFA genes, followed by expression violations of E-cadherin, β-catenin, VEGFA encod...

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Bibliographic Details
Main Authors: V. A. Tumanskiy, A. V. Chepets, А. М. Kamyshnyi
Format: Article
Language:English
Published: Zaporozhye State Medical University 2016-08-01
Series:Patologìâ
Subjects:
Endometrial Neoplasms
Cadherins
beta Catenin
VEGFA protein
Human
Polymerase Chain Reaction
RNA
Messenger
Online Access:http://pat.zsmu.edu.ua/article/view/81328/78220

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