Impact of cytotoxin-associated gene A of <i>Helicobacter pylori </i>strains on microalbuminuria in type 2 diabetes

• Main Authors: Ibrahim Amany, Zaher Tarik, Ghonemy Tarek, El-Azim Shymaa, El-Azim Marwa, Ramadan Ayman
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Saudi Journal of Kidney Diseases and Transplantation
• Online Access: http://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=4;spage=694;epage=700;aulast=Ibrahim

Cytotoxin-associated gene <i>A (CagA) </i>positive strains of <i>H. pylori </i>have a significant correlation with gastritis and peptic ulcer, and may induce persistent systemic inflammatory response, increase vascular damage, and compromise glycemic control in diabetic patients. To evaluate correlation between infection by <i>cagA </i>positive strains of <i>H. pylori </i>and occurrence of microalbuminuria and glycemic control in type 2 diabetic patients, we prospectively studied 98 dyspeptic type 2 diabetic patients as a study group and 102 dyspeptic non-diabetic subjects as a control group. Gastric biopsy specimens obtained with endoscopy were cultured to isolate <i>H. pylori. </i>All the isolated <i> H. pylori </i>strains from cultures were used for detection of <i>cagA </i>gene by polymerase chain reaction. There was no significant difference between study and control groups regarding infection with <i>cagA </i>positive strains of <i> H. pylori </i>(<i> P</i>= 0.145). Furthermore, there was no significant differences between both groups concerning the incidence of microalbuminuria (<i> P</i>= 0.145). On the other hand, there was an extremely statistically significant difference in the inci-dence of microalbuminuria and glycemic control in the diabetic patients between those infected with <i>cagA </i>positive strains of H. pylori </i>and cag A negative starins (P</i>= 0.000). We conclude that infection with cagA </i>positive strains of H. pylori </i>are strongly associated with the increased inci-dence of microalbuminuria and poor glycemic control in type 2 diabetic patients.