| Summary: | Cytotoxin-associated gene <i>A (CagA) </i>positive strains of <i>H. pylori </i>have a significant correlation with gastritis and peptic ulcer, and may induce persistent systemic inflammatory response, increase vascular damage, and compromise glycemic control in diabetic patients. To evaluate correlation between infection by <i>cagA </i>positive strains of <i>H. pylori </i>and occurrence of microalbuminuria and glycemic control in type 2 diabetic patients, we prospectively studied 98 dyspeptic type 2 diabetic patients as a study group and 102 dyspeptic non-diabetic subjects as a control group. Gastric biopsy specimens obtained with endoscopy were cultured to isolate <i>H. pylori. </i>All the isolated <i> H. pylori </i>strains from cultures were used for detection of <i>cagA </i>gene by polymerase chain reaction. There was no significant difference between study and control groups regarding infection with <i>cagA </i>positive strains of <i> H. pylori </i>(<i> P</i>= 0.145). Furthermore, there was no significant differences between both groups concerning the incidence of microalbuminuria (<i> P</i>= 0.145). On the other hand, there was an extremely statistically significant difference in the inci-dence of microalbuminuria and glycemic control in the diabetic patients between those infected with <i>cagA </i>positive strains of H. pylori </i>and cag A negative starins (P</i>= 0.000). We conclude that infection with cagA </i>positive strains of H. pylori </i>are strongly associated with the increased inci-dence of microalbuminuria and poor glycemic control in type 2 diabetic patients.
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