Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy
Background. Periodontal disease is a chronic inflammatory condition affecting the supporting structures of the dentition. Periodontal destruction is an outcome of the imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs). We wanted to prove the hypoth...
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doaj-74282b3b74bc417ea6f46665ea716f912020-11-24T23:47:37ZengHindawi LimitedInternational Journal of Chronic Diseases2356-69812314-57492014-01-01201410.1155/2014/363581363581Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal TherapyAngel Fenol0Maya Rajan Peter1Jayachandran Perayil2Rajesh Vyloppillil3Anuradha Bhaskar4Department of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaDepartment of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaDepartment of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaDepartment of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaDepartment of Periodontics, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaBackground. Periodontal disease is a chronic inflammatory condition affecting the supporting structures of the dentition. Periodontal destruction is an outcome of the imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs). We wanted to prove the hypothesis that salivary TIPM-1 level will vary in different people. A decrease in TIMP-1 level could make them more susceptible to periodontitis whereas a normal level could prevent increased tissue destruction thereby inhibiting the progression from gingivitis to periodontitis. This could probably pave the way for TIPM-1 to be a specific salivary biomarker and serve as a useful diagnostic and therapeutic tool in periodontitis. Methods. Whole unstimulated saliva of 2 ml was collected from twenty-five periodontally healthy and twenty-seven systemically healthy subjects with periodontitis. Clinical parameters recorded at baseline and reevaluated after four weeks in subjects with periodontitis following nonsurgical periodontal therapy were gingival index (GI), oral hygiene index-Simplified (OHI-S), probing pocket depth, and clinical attachment level (CAL). Salivary TIMP-1 levels in both were analyzed using a commercially available ELISA kit.http://dx.doi.org/10.1155/2014/363581 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Angel Fenol Maya Rajan Peter Jayachandran Perayil Rajesh Vyloppillil Anuradha Bhaskar |
spellingShingle |
Angel Fenol Maya Rajan Peter Jayachandran Perayil Rajesh Vyloppillil Anuradha Bhaskar Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy International Journal of Chronic Diseases |
author_facet |
Angel Fenol Maya Rajan Peter Jayachandran Perayil Rajesh Vyloppillil Anuradha Bhaskar |
author_sort |
Angel Fenol |
title |
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy |
title_short |
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy |
title_full |
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy |
title_fullStr |
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy |
title_full_unstemmed |
Comparison of Salivary TIMP-1 Levels in Periodontally Involved and Healthy Controls and the Response to Nonsurgical Periodontal Therapy |
title_sort |
comparison of salivary timp-1 levels in periodontally involved and healthy controls and the response to nonsurgical periodontal therapy |
publisher |
Hindawi Limited |
series |
International Journal of Chronic Diseases |
issn |
2356-6981 2314-5749 |
publishDate |
2014-01-01 |
description |
Background. Periodontal disease is a chronic inflammatory condition affecting the supporting structures of the dentition. Periodontal destruction is an outcome of the imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs). We wanted to prove the hypothesis that salivary TIPM-1 level will vary in different people. A decrease in TIMP-1 level could make them more susceptible to periodontitis whereas a normal level could prevent increased tissue destruction thereby inhibiting the progression from gingivitis to periodontitis. This could probably pave the way for TIPM-1 to be a specific salivary biomarker and serve as a useful diagnostic and therapeutic tool in periodontitis. Methods. Whole unstimulated saliva of 2 ml was collected from twenty-five periodontally healthy and twenty-seven systemically healthy subjects with periodontitis. Clinical parameters recorded at baseline and reevaluated after four weeks in subjects with periodontitis following nonsurgical periodontal therapy were gingival index (GI), oral hygiene index-Simplified (OHI-S), probing pocket depth, and clinical attachment level (CAL). Salivary TIMP-1 levels in both were analyzed using a commercially available ELISA kit. |
url |
http://dx.doi.org/10.1155/2014/363581 |
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