Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

The epithelial to mesenchymal transition (EMT) is characterized by a loss of cell polarity, a decrease in the epithelial cell marker E-cadherin, and an increase in mesenchymal markers including the zinc-finger E-box binding homeobox (ZEB1). The EMT is also associated with an increase in cell migrati...

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Bibliographic Details
Main Authors: Akshita B. Bhatt, Thomas D. Wright, Van Barnes, Suravi Chakrabarty, Margarite D. Matossian, Erin Lexner, Deniz A. Ucar, Lucio Miele, Patrick T. Flaherty, Matthew E. Burow, Jane E. Cavanaugh
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Translational Oncology
Subjects:
ERK1/2
ERK5
Mesenchymal to epithelial transition (MET)
Signaling
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000383

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