Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway

Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway

T-2 toxin, a trichothecene mycotoxin produced by <i>Fusarium</i>, is widely distributed in crops and animal feed and frequently induces intestinal damage. Betulinic acid (BA), a plant-derived pentacyclic lupane-type triterpene, possesses potential immunomodulatory, antioxidant and anti-i...

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Bibliographic Details
Main Authors: Chenxi Luo, Chenglong Huang, Lijuan Zhu, Li Kong, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Jine Yi
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Toxins
Subjects:
T-2 toxin
betulinic acid
intestine
oxidative damage
NF-κB signaling pathway
Online Access:https://www.mdpi.com/2072-6651/12/12/794

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