Increased levels of 5′,8-Cyclopurine DNA lesions in inflammatory bowel diseases

Increased levels of 5′,8-Cyclopurine DNA lesions in inflammatory bowel diseases

Chronic inflammation is estimated to be a causative factor in a variety of diseases. Under inflammatory conditions reactive oxygen species (ROS) and nitrogen species (RNS) are released leading to DNA damage accumulation and genomic instability. Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are oxidati...

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Bibliographic Details
Main Authors: Annalisa Masi, Paola Fortini, Marios G. Krokidis, Erminia Francesca Romeo, Cinzia Bascietto, Paola De Angelis, Valeria Guglielmi, Chryssostomos Chatgilialoglu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
Reactive oxygen species
Free radicals
DNA damage
Cyclopurines
Inflammatory bowel diseases
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720303712

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