Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence

Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence

Alkaline phosphatase (AP) is an enzyme that exhibits anti-inflammatory effects by dephosphorylating inflammation triggering moieties (ITMs) like bacterial lipopolysaccharides and extracellular nucleotides. AP administration aims to prevent and treat peri- and post-surgical ischemia reperfusion injur...

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Bibliographic Details
Main Authors: Alva Presbitero, Emiliano Mancini, Ruud Brands, Valeria V. Krzhizhanovskaya, Peter M. A. Sloot
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
alkaline phosphatase
innate immune response
cardiac surgery
ODE model
in-silico
clinical trial
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02342/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02342/full

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