Autophagy Disruptions Associated With Altered Optineurin Expression in Extranigral Regions in a Rotenone Model of Parkinson's Disease

The motor features of Parkinson's disease (PD) primarily result from a lesion to the nigrostriatal dopamine system. Numerous non-motor symptoms occur in PD, many of which are postulated to stem from pathology outside of the nigrostriatal dopamine system. Perturbations to protein trafficking, di...

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Bibliographic Details
Main Authors: John P. Wise, Charles G. Price, Joseph A. Amaro, Jason R. Cannon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroscience
Subjects:
LC3
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00289/full