SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation

SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation

Abstract.: SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-1, and B16F10) and human umbilical vein endothelia...

Full description

Bibliographic Details
Main Authors:	Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie, Lijuan Chen
Format:	Article
Language:	English
Published:	Elsevier 2014-04-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131930074X

Similar Items

PI3K/AKT/mTOR pathway in Angiogenesis
by: Jayashree eKarar, et al.
Published: (2011-12-01)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
by: Wen Wen, et al.
Published: (2020-09-01)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
by: Kerstin Tiedemann, et al.
Published: (2017-05-01)

The paradox of Akt -mTOR interactions
by: LAKSHMIPATHI eVADLAKONDA, et al.
Published: (2013-06-01)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
by: Juan Du, et al.
Published: (2016-01-01)

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D
by: Razmara Masoud, et al.
Published: (2013-01-01)

Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer
by: Rajani Rai, et al.
Published: (2020-05-01)

Akt and mTOR in B cell activation and differentiation
by: David A. Fruman, et al.
Published: (2012-08-01)

Inhibition effects of 7-phloro-eckol from Ecklonia cava on metastasis and angiogenesis induced by hypoxia through regulation of AKT/mTOR and ERK signaling pathways
by: Shengtao Yang, et al.
Published: (2021-06-01)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer.
by: Guo-Dong Cao, et al.
Published: (2016-01-01)

mTOR-dependent phosphorylation controls TFEB nuclear export
by: Gennaro Napolitano, et al.
Published: (2018-08-01)

Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
by: Chih-Ya Wang, et al.
Published: (2012-01-01)

Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.
by: Jae Sung You, et al.
Published: (2012-01-01)

mTOR signaling pathway and mTOR inhibitors in the treatment of cancer
by: Mehmet Küçüköner, et al.
Published: (2013-03-01)

Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins.
by: Janna E Hutz, et al.
Published: (2011-01-01)

Carcinoma da bexiga: via de sinalização PI3K/Akt/mTOR e inibidores do mTOR
by: Maria do Céu dos Santos Silva Costa
Published: (2019)

mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes.
by: Antonia Patruno, et al.
Published: (2015-01-01)

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.
by: Maikel A Farhan, et al.
Published: (2015-01-01)

Akt1 enhances CA916798 expression through mTOR pathway.
by: Yu-Liang Wang, et al.
Published: (2013-01-01)

Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway
by: Yingjun Zhu, et al.
Published: (2020-02-01)

BCAT1 Activates PI3K/AKT/mTOR Pathway and Contributes to the Angiogenesis and Tumorigenicity of Gastric Cancer
by: Xiong Shu, et al.
Published: (2021-06-01)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
by: Zhilin Zou, et al.
Published: (2020-03-01)

Glutamate Transporter-Dependent mTOR Phosphorylation in Müller Glia Cells
by: Ana María López-Colomé, et al.
Published: (2012-07-01)

Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues
by: Hojung Lee
Published: (2017-01-01)

PI3K/Akt/mTOR inhibitors in breast cancer
by: Joycelyn JX Lee, et al.
Published: (2015-12-01)

Targeting PI3K/Akt/mTOR Signaling In Cancer
by: Camillo ePorta, et al.
Published: (2014-04-01)

Rapamycin-Induced Apoptosis in HGF-Stimulated Lens Epithelial Cells by AKT/mTOR, ERK and JAK2/STAT3 Pathways
by: Fang Tian, et al.
Published: (2014-08-01)

The Akt/mTOR Pathway and Estrogen Receptor Phosphorylations : a crosstalk with potential to predict tamoxifen resistance in breast cancer
by: Bostner, Josefine
Published: (2013)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
by: Leal P, et al.
Published: (2013-10-01)

Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway.
by: Zhiqing Fang, et al.
Published: (2013-01-01)

Activation of Akt/mTOR pathway is associated with poor prognosis of nasopharyngeal carcinoma.
by: Weiyuan Wang, et al.
Published: (2014-01-01)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
by: Tian Tian, et al.
Published: (2019-02-01)

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling
by: Jing Xu, et al.
Published: (2019-11-01)

NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/ mTOR phosphorylation
by: Sun ZH, et al.
Published: (2015-01-01)

Regulation of the lipid kinase VPS34 by mTOR-mediated UVRAG phosphorylation
by: Munson, Michael
Published: (2014)

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.
by: Heloisa P Soares, et al.
Published: (2013-01-01)

Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways.
by: Yingying Shi, et al.
Published: (2015-01-01)

Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer
by: Sanjay Mishra, et al.
Published: (2021-04-01)

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials
by: Choudhary Harsha, et al.
Published: (2020-05-01)

AKTivation of the PI3K/AKT/mTOR signaling pathway by KSHV
by: Aadra P Bhatt, et al.
Published: (2013-01-01)