Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) is a powerful tool to identify tau-targeted therapeutics. However, such screens have been...

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Bibliographic Details
Main Authors: Chao Wang, Michael E. Ward, Robert Chen, Kai Liu, Tara E. Tracy, Xu Chen, Min Xie, Peter Dongmin Sohn, Connor Ludwig, Anke Meyer-Franke, Celeste M. Karch, Sheng Ding, Li Gan
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
human induced pluripotent stem cells
human neurons
Tau-lowering
neurogenin 2
high-content screening
adrenergic receptor
Alzheimer’s disease
tau
frontotemporal dementia
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303764

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http://www.sciencedirect.com/science/article/pii/S2213671117303764

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