Metabolomic Analysis of Platelets of Patients With Aspirin Non-Response

Metabolomic Analysis of Platelets of Patients With Aspirin Non-Response

Background: Aspirin is the most commonly used antiplatelet agent for the prevention of cardiovascular diseases. However, a certain proportion of patients do not respond to aspirin therapy. The mechanisms of aspirin non-response remain unknown. The unique metabolomes in platelets of patients with cor...

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Main Authors: Jiun-Yang Chiang, Sheng-Han Lee, Yen-Ching Chen, Cho-Kai Wu, Jing-Yuan Chuang, Shyh-Chyi Lo, Huei-Ming Yeh, Shih-Fan Sherri Yeh, Cheng-An Hsu, Bin-Bin Lin, Pi-Chu Chang, Chih-Hsin Chang, Hao-Jan Liang, Fu-Tien Chiang, Ching-Yu Lin, Jyh-Ming Jimmy Juang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
aspirin non-response
metabolomics
PFA-100
glycine
platelet
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01107/full

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