Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders

Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders

CAG repeat instability causes a number of neurodegenerative disorders. The unusual hairpin stem structure formed by the CAG repeats in DNA traps the human mismatch repair MSH2.MSH3 (Mutsβ) complex. To understand the mechanism behind the abnormal binding of Mutsβ with the imperfect hairpin stem struc...

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Bibliographic Details
Main Authors: Yogeeshwar Ajjugal, Thenmalarchelvi Rathinavelan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
CAG repeat expansion
Polyglutamine diseases
MSH2.MSH3
Molecular dynamics simulations
A…A mismatch
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021003081

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