The change of character of a passing of a Grave’s disease in St. Petersburg from 1970 till 2010

• Format: Article
• Language: Russian
• Published: Endocrinology Research Centre 2012-06-01
• Series: Клиническая и экспериментальная тиреоидология
• Subjects: grave’s disease; iodine deficiency; median urinary iodine concentration; iodine status
• Online Access: https://cet-endojournals.ru/ket/article/viewFile/4275/2412

The first time the assessment of an iodine status of St. Petersburg was carried out in 1999 by the staff of faculty therapy of Saint-Petersburg State Medical University named after academician I.P Pavlov. The median urinary iodine concentration was 105 mkg/l. In 2010 the iodine status of St. Petersburg was carried out again: the median urinary iodine concentration was significantly higher – 148 mkg/l. In this regard it was reasonable to carry out comparison of indicators of a iodine status St. Petersburg and the features of a course of a Grave’s disease before the beginning of actions for elimination of iodine deficiency (till 1999) and during active of iodine prophylaxis. There were 310 patients with a Grave’s disease, they were diagnosed during the period from 1970 to 2010. From 1980 to 2010 the number of remissions of a disease gradually decreased: till 1990 the number of remissions was 21.7% whereas from2006 to 2011 the remissions were noted at 3.9% of patients with a diffuse toxic goiter. The group of patients with disease recurrence was separately analysed. Till 1990 among the patients with recurrence of a disease developed in 207.00 ± 35.18 months, in the group of the diseased in 1990–1995 – in 73.00 ± 13.95 months, in the group among the diseased in 1996–2000 – in 22.86 ± 3.46 months, in the group 2001–2005 – in 28.59 ± 5.19 month, and in 2006–2011 – in 7.75 ± 1.21 months.The carried-out research showed that for the last 20 years the essential change of character of a course of a Grave’s disease noted. It is possible to suppose that the revealed features, most likely are connected with the change of a iodine status of the region.